Blood–retinal barrier

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The blood–retinal barrier, or the BRB, is part of the blood–ocular barrier that consists of cells that are joined tightly together to prevent certain substances from entering the tissue of the retina. Blood–retinal barrier_sentence_0

It consists of non-fenestrated capillaries of the retinal circulation and tight-junctions between retinal epithelial cells preventing passage of large molecules from choriocapillaris into the retina. Blood–retinal barrier_sentence_1

Structure Blood–retinal barrier_section_0

The blood retinal barrier has two components: the retinal vascular endothelium and the retinal pigment epithelium. Blood–retinal barrier_sentence_2

Retinal blood vessels that are similar to cerebral blood vessels maintain the inner blood-ocular barrier. Blood–retinal barrier_sentence_3

This physiological barrier comprises a single layer of non-fenestrated endothelial cells, which have tight junctions. Blood–retinal barrier_sentence_4

These junctions are impervious to tracer, so many substances can affect the metabolism of the eyeball. Blood–retinal barrier_sentence_5

The retinal pigment epithelium maintains the outer blood–retinal barrier. Blood–retinal barrier_sentence_6

Clinical significance Blood–retinal barrier_section_1

Diabetic retinopathy Blood–retinal barrier_section_2

Diabetic retinopathy, eye damage that frequently occurs as a result of diabetes, is related to the breakdown of the blood–retinal barrier. Blood–retinal barrier_sentence_7

The barrier becomes more leaky in patients with diabetic retinopathy. Blood–retinal barrier_sentence_8

Other animals Blood–retinal barrier_section_3

Animal models have shown that the blood–retinal barrier becomes more permeable to substances in hypertensive animals (those with high blood pressure). Blood–retinal barrier_sentence_9

See also Blood–retinal barrier_section_4

Blood–retinal barrier_unordered_list_0

  • Blood–air barrier – Membrane separating alveolar air from blood in lung capillariesBlood–retinal barrier_item_0_0
  • Blood–brain barrier – Semipermeable capillary border that allows selective passage of blood constituents into the brainBlood–retinal barrier_item_0_1
  • Blood–ocular barrier – A physical barrier between the local blood vessels and most parts of the eye itselfBlood–retinal barrier_item_0_2
  • Blood–testis barrier – A physical barrier between the blood vessels and the seminiferous tubules of the animal testesBlood–retinal barrier_item_0_3
  • Blood–thymus barrier – A barrier formed by the continuous blood capillaries in the thymic cortexBlood–retinal barrier_item_0_4


Credits to the contents of this page go to the authors of the corresponding Wikipedia page: en.wikipedia.org/wiki/Blood–retinal barrier.