A chondrosarcoma is a member of a category of tumors of bone and soft tissue known as sarcomas.
About 30% of bone sarcomas are chondrosarcomas.
Unlike other primary bone sarcomas that mainly affect children and adolescents, a chondrosarcoma can present at any age.
|Subtype||Percentage of cases %|
|Periosteal (aka juxtacortical)||<1%|
Symptoms and signs
The cause is unknown.
In a few cases, usually of highly anaplastic tumors, immunohistochemistry (IHC) is required.
There are no blood tests currently available to enable an oncologist to render a diagnosis of chondrosarcoma.
The most characteristic imaging findings are usually obtained with CT.
Nearly all chondrosarcoma patients appear to be in good health.
Often, patients are not aware of the growing tumor until there is a noticeable lump or pain.
Earlier diagnosis is generally accidental, when a patient undergoes testing for another problem and physicians discover the cancer.
Occasionally the first symptom will be a broken bone at the cancerous site.
Any broken bone that occurs from mild trauma warrants further investigation, although there are many conditions that can lead to weak bones, and this form of cancer is not a common cause of such breaks.
Treatment depends on the location of the disease and the aggressiveness of the tumors.
Because chondrosarcomas are rare, they are treated at specialist hospitals with Sarcoma Centers.
Surgery is the main form of treatment for chondrosarcoma.
Musculoskeletal tumor specialists or orthopedic oncologists are usually chosen to treat chondrosarcoma, unless it is located in the skull, spine, or chest cavity, in which case, a neurosurgeon or thoracic surgeon experienced with sarcomas is chosen.
Often, a limb-sparing operation can be performed, but in some cases amputation is unavoidable.
There are two kinds of hemipelvectomy - internal and external.
- External hemipelvectomy - is removal of that half of the pelvis with the amputation of the leg. It is also called the hindquarter amputation.
- Internal hemipelvectomy - is removal of that half of the pelvis, but the leg is left intact.
Amputation at the hip is called hip disarticulation and amputees who have had this amputation are also called hip disartics.
Chemotherapy or traditional radiotherapy are not very effective for most chondrosarcomas, although proton therapy is showing promise with local tumor control at over 80%.
Complete surgical ablation is the most effective treatment, but sometimes this is difficult.
Proton therapy radiation can be useful in awkward locations to make surgery more effective.
Prognosis depends on how early the cancer is discovered and treated.
For the least aggressive grade, about 90% of patients survive more than five years after diagnosis.
People usually have a good survival rate at the low grade volume of cancer.
For the most aggressive grade, only 10% of patients will survive one year.
Tumors may recur in the future.
Follow up scans are extremely important for chondrosarcoma to make sure there has been no recurrence or metastasis, which usually occurs in the lungs.
Credits to the contents of this page go to the authors of the corresponding Wikipedia page: en.wikipedia.org/wiki/Chondrosarcoma.