Type I collagen

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Type I collagen_table_infobox_0

collagen, type I, alpha 1Type I collagen_header_cell_0_0_0
IdentifiersType I collagen_header_cell_0_1_0
SymbolType I collagen_header_cell_0_2_0 COL1A1Type I collagen_cell_0_2_1
NCBI geneType I collagen_header_cell_0_3_0 Type I collagen_cell_0_3_1
HGNCType I collagen_header_cell_0_4_0 Type I collagen_cell_0_4_1
OMIMType I collagen_header_cell_0_5_0 Type I collagen_cell_0_5_1
RefSeqType I collagen_header_cell_0_6_0 Type I collagen_cell_0_6_1
UniProtType I collagen_header_cell_0_7_0 Type I collagen_cell_0_7_1
Other dataType I collagen_header_cell_0_8_0
LocusType I collagen_header_cell_0_9_0 Chr. 17Type I collagen_cell_0_9_1
Search forStructuresDomainsType I collagen_cell_0_10_0
Search forType I collagen_header_cell_0_11_0
StructuresType I collagen_header_cell_0_12_0 Type I collagen_cell_0_12_1
DomainsType I collagen_header_cell_0_13_0 Type I collagen_cell_0_13_1

Type I collagen_table_infobox_1

collagen, type I, alpha 2Type I collagen_header_cell_1_0_0
IdentifiersType I collagen_header_cell_1_1_0
SymbolType I collagen_header_cell_1_2_0 COL1A2Type I collagen_cell_1_2_1
Alt. symbolsType I collagen_header_cell_1_3_0 OI4Type I collagen_cell_1_3_1
NCBI geneType I collagen_header_cell_1_4_0 Type I collagen_cell_1_4_1
HGNCType I collagen_header_cell_1_5_0 Type I collagen_cell_1_5_1
OMIMType I collagen_header_cell_1_6_0 Type I collagen_cell_1_6_1
RefSeqType I collagen_header_cell_1_7_0 Type I collagen_cell_1_7_1
UniProtType I collagen_header_cell_1_8_0 Type I collagen_cell_1_8_1
Other dataType I collagen_header_cell_1_9_0
LocusType I collagen_header_cell_1_10_0 Chr. 7Type I collagen_cell_1_10_1
Search forStructuresDomainsType I collagen_cell_1_11_0
Search forType I collagen_header_cell_1_12_0
StructuresType I collagen_header_cell_1_13_0 Type I collagen_cell_1_13_1
DomainsType I collagen_header_cell_1_14_0 Type I collagen_cell_1_14_1

Type I collagen is the most abundant collagen of the human body. Type I collagen_sentence_0

It forms large, eosinophilic fibers known as collagen fibers. Type I collagen_sentence_1

It is present in scar tissue, the end product when tissue heals by repair, as well as tendons, ligaments, the endomysium of myofibrils, the organic part of bone, the dermis, the dentin, and organ capsules. Type I collagen_sentence_2

Formation Type I collagen_section_0

The COL1A1 gene produces the pro-alpha1(I) chain. Type I collagen_sentence_3

This chain combines with another pro-alpha1(I) chain and also with a pro-alpha2(I) chain (produced by the COL1A2 gene) to make a molecule of type I procollagen. Type I collagen_sentence_4

These triple-stranded, rope-like procollagen molecules must be processed by enzymes outside the cell. Type I collagen_sentence_5

Once these molecules are processed, they arrange themselves into long, thin fibrils that cross-link to one another in the spaces around cells. Type I collagen_sentence_6

The cross-links result in the formation of very strong mature type I collagen fibers. Type I collagen_sentence_7

Clinical significance Type I collagen_section_1

See Collagen, type I, alpha 1#Clinical significance Type I collagen_sentence_8

See also Type I collagen_section_2

Type I collagen_unordered_list_0

Credits to the contents of this page go to the authors of the corresponding Wikipedia page: en.wikipedia.org/wiki/Type I collagen.