Blood–ocular barrier

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The blood–ocular barrier is a barrier created by endothelium of capillaries of the retina and iris, ciliary epithelium and retinal pigment epithelium. Blood–ocular barrier_sentence_0

It is a physical barrier between the local blood vessels and most parts of the eye itself, and stops many substances including drugs from traveling across it. Blood–ocular barrier_sentence_1

Inflammation can break down this barrier allowing drugs and large molecules to penetrate into the eye. Blood–ocular barrier_sentence_2

As the inflammation subsides, this barrier usually returns. Blood–ocular barrier_sentence_3

It consists of the following components: Blood–ocular barrier_sentence_4

Blood–ocular barrier_unordered_list_0

  • Blood–aqueous barrier: the ciliary epithelium and capillaries of the iris. Blood-aqueous barrier is formed by nonpigmented ciliary epithelial cells of the ciliary body and endothelial cells of blood vessels in the iris.Blood–ocular barrier_item_0_0
  • Blood–retinal barrier: non-fenestrated capillaries of the retinal circulation and tight-junctions between retinal epithelial cells preventing passage of large molecules from choriocapillaris into the retina. Formed by endothelium of retinal vessels and epithelium of retinal pigment.Blood–ocular barrier_item_0_1

See also Blood–ocular barrier_section_0

Blood–ocular barrier_unordered_list_1

  • Blood–air barrier – Membrane separating alveolar air from blood in lung capillariesBlood–ocular barrier_item_1_2
  • Blood–brain barrier – Semipermeable capillary border that allows selective passage of blood constituents into the brainBlood–ocular barrier_item_1_3
  • Blood–retinal barrier – Part of the blood–ocular barrier that prevents certain substances from entering the retinaBlood–ocular barrier_item_1_4
  • Blood–testis barrier – A physical barrier between the blood vessels and the seminiferous tubules of the animal testesBlood–ocular barrier_item_1_5
  • Blood–thymus barrier – A barrier formed by the continuous blood capillaries in the thymic cortexBlood–ocular barrier_item_1_6


Credits to the contents of this page go to the authors of the corresponding Wikipedia page: en.wikipedia.org/wiki/Blood–ocular barrier.