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Not to be confused with metaphysics. Metaphysis_sentence_0


PronunciationMetaphysis_header_cell_0_2_0 /mətˈæfɪsɪs/Metaphysis_cell_0_2_1
Part ofMetaphysis_header_cell_0_3_0 Long bonesMetaphysis_cell_0_3_1
LatinMetaphysis_header_cell_0_5_0 metaphysisMetaphysis_cell_0_5_1
TA98Metaphysis_header_cell_0_6_0 Metaphysis_cell_0_6_1
TA2Metaphysis_header_cell_0_7_0 Metaphysis_cell_0_7_1
FMAMetaphysis_header_cell_0_8_0 Metaphysis_cell_0_8_1

The metaphysis is the neck portion of a long bone between the epiphysis and the diaphysis. Metaphysis_sentence_1

It contains the growth plate, the part of the bone that grows during childhood, and as it grows it ossifies near the diaphysis and the epiphyses. Metaphysis_sentence_2

The metaphysis contains a diverse population of cells including mesenchymal stem cells, which give rise to bone and fat cells, as well as hematopoietic stem cells which give rise to a variety of blood cells as well as bone-destroying cells called osteoclasts. Metaphysis_sentence_3

Thus the metaphysis contains a highly metabolic set of tissues including trabecular (spongy) bone, blood vessels , as well as Marrow Adipose Tissue (MAT). Metaphysis_sentence_4

The metaphysis may be divided anatomically into three components based on tissue content: a cartilaginous component (epiphyseal plate), a bony component (metaphysis) and a fibrous component surrounding the periphery of the plate. Metaphysis_sentence_5

The growth plate synchronizes chondrogenesis with osteogenesis or interstitial cartilage growth with appositional bone growth at the same that it is growing in width, bearing load and responding to local and systemic forces and factors. Metaphysis_sentence_6

During childhood, the growth plate contains the connecting cartilage enabling the bone to grow; at adulthood (between the ages of 18 to 25 years), the components of the growth plate stop growing altogether and completely ossify into solid bone. Metaphysis_sentence_7

In an adult, the metaphysis functions to transfer loads from weight-bearing joint surfaces to the diaphysis. Metaphysis_sentence_8

Clinical significance Metaphysis_section_0

Because of their rich blood supply and vascular stasis, metaphyses of long bones are prone to hematogenous spread of osteomyelitis in children. Metaphysis_sentence_9

Metaphyseal tumors or lesions include osteosarcoma, chondrosarcoma, fibrosarcoma, osteoblastoma, enchondroma, fibrous dysplasia, simple bone cyst, aneurysmal bone cyst, non-ossifying fibroma, and osteoid osteoma. Metaphysis_sentence_10

One of the clinical signs of rickets that doctors look for is cupping and fraying at the metaphyses when seen on X-ray. Metaphysis_sentence_11

See also Metaphysis_section_1


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