Osteolysis

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Osteolysis_table_infobox_0

OsteolysisOsteolysis_header_cell_0_0_0
SpecialtyOsteolysis_header_cell_0_1_0 OrthopedicsOsteolysis_cell_0_1_1

Osteolysis is an active resorption of bone matrix by osteoclasts and can be interpreted as the reverse of ossification. Osteolysis_sentence_0

Although osteoclasts are active during the natural formation of healthy bone the term "osteolysis" specifically refers to a pathological process. Osteolysis_sentence_1

Osteolysis often occurs in the proximity of a prosthesis that causes either an immunological response or changes in the bone's structural load. Osteolysis_sentence_2

Osteolysis may also be caused by pathologies like bone tumors, cysts, or chronic inflammation. Osteolysis_sentence_3

Joint replacement Osteolysis_section_0

While bone resorption is commonly associated with many diseases or joint problems, the term osteolysis generally refers to a problem common to artificial joint replacements such as total hip replacements, total knee replacements and total shoulder replacements. Osteolysis_sentence_4

Osteolysis can also be associated with the radiographic changes seen in those with bisphosphonate-related osteonecrosis of the jaw. Osteolysis_sentence_5

There are several biological mechanisms which may lead to osteolysis. Osteolysis_sentence_6

In total hip replacement, the generally accepted explanation for osteolysis involves wear particles (worn off the contact surface of the artificial ball and socket joint). Osteolysis_sentence_7

As the body attempts to clean up these wear particles (typically consisting of plastic or metal), it triggers an autoimmune reaction which causes resorption of living bone tissue. Osteolysis_sentence_8

Osteolysis has been reported to occur as early as 12 months after implantation and is usually progressive. Osteolysis_sentence_9

This may require a revision surgery (replacement of the prosthesis). Osteolysis_sentence_10

Although osteolysis itself is clinically asymptomatic, it can lead to implant loosening or bone breakage, which in turn causes serious medical problems. Osteolysis_sentence_11

Distal clavicular osteolysis Osteolysis_section_1

Distal clavicular osteolysis (DCO) is often associated with problems weightlifters have with their acromioclavicular joints due to high stresses put on the clavicle as it meets with the acromion. Osteolysis_sentence_12

This condition is often referred to as "weight lifter's shoulder". Osteolysis_sentence_13

Medical ultrasonography readily depicts resorption of the distal clavicle as irregular cortical erosions, whereas the acromion remains intact. Osteolysis_sentence_14

Associated findings may include distended joint capsule, soft-tissue swelling, and joint instability. Osteolysis_sentence_15

A common surgery to treat recalcitrant DCO is re-sectioning of the distal clavicle, removing a few millimetres of bone from the very end of the bone. Osteolysis_sentence_16

See also Osteolysis_section_2

Osteolysis_unordered_list_0


Credits to the contents of this page go to the authors of the corresponding Wikipedia page: en.wikipedia.org/wiki/Osteolysis.